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许慧玲

许慧玲(Huiling Xu),澳大利亚籍,1963年生于中国云南省昆明市。澳大利亚PeterMacCallum癌症研究中心研究生管理委员会委员、澳大利亚国家医学科学研究基金审评员、“乳腺癌研究及治疗”杂志评委。目前在Peter MacCallum癌症研究中心高级研究员并兼职墨尔本大学医学院荣誉高级研究员。

1983年毕业于云南大学生物系,获学士学位。1986年于北京林业大学生物技术中心,获硕士学位。同年,就职于北京林业大学生物技术中心。1992年于墨尔本大学科学院获得博士学位。并与1992-1996年在墨尔本大学科学院植物系进行博士后研究工作。同年,就职于墨尔本大学森林资源学院植物细胞分子生物学中心,担任研究员。1999年至今在PeterMacCallum癌症研究中心高级研究员,并于2005年至今兼职墨尔本大学医学院荣誉高级研究员。 

许慧玲博士目前在澳大利亚唯一所专业癌症研究中心(Peter MacCallum Cancer Centre)从事癌细胞分子生物学研究。其研究对有关控制细胞分裂的机制做出了特殊的贡献。多次获得澳大利亚国家医学科学研癌症基金会和澳大利亚国家自然科学研究基金。研究成果得到国际同行的好评,曾多次应邀与美国,英国,法国同行合作并在国际会议做报告。在墨尔本大学仼职期间,许慧玲博士主要从亊植物细胞及分子生物学研究。成功的分离出第一个植物雄性特有基因并获得二项国际(美国及澳大利亚)专利。目前主持完成4项澳大利亚国家医学科学研究基金,1项癌症基金会基金,1项墨尔本大学森林资源学院资助基金,总金额约200万澳元。 

许慧玲博士至今共发表40余篇科研文章及二篇特邀综述。其中一篇综述是应邀发表在最权威的杂志之一《Nat Rev Cancer》,并有多篇科研文章发表于生命科学权威杂志上。包括《DevelopmentalCell》,《Cell》,《EMBO Reports》,《Breast Cancer Res》,《PNAS(二篇)》,《Plant Cell》,《Plant Journal》等。 

代表性科研文章:

1. Xu H*, Deb S.*, et al. (2014) RAD21cohesin over-expression is a prognostic and predictive marker exacerbating poorprognosis in KRAS mutant colorectal carcinomas. British Journal of Cancer.2014. 

2. Sampurno, S., Bijenhof, A., Cheasley,D., Xu, H., Robine, S., Hilton, D., Alexander, W.S., Pereira, L.,Mantamadiotis, T., Malaterre, J., and Ramsay R.G , The Myb-p300-CREB Axis ModulatesIntestine Homeostasis, Radiosensitivity and Tumorigenesis. Cell Death andDisease, 2013. 

3. Murdoch, B., Owen, N., Stevense, M.,Smith, H., Nagaoka, S., Hassold, T., McKay, M., Xu, H., Fu, J., Revenkova, E.,Jessberger, R. and Hunt, P. Altered cohesin gene dosage affects Mammalianmeiotic chromosome structure and behavior. PLoS Genet, 2013. 9(2): p. e1003241. 

4. Xu, H.*, Yan, M*., Waddell, N.,Shield-Artin, K., Haviv, I., McKay, M. J., and Fox, S. B., Enhanced RAD21cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1familial breast cancers. Breast Cancer Res, 2012. 14(2): p. R69. 

5. Faure, A. J., Schmidt, D., Watt, S.,Schwalie, P. C., Wilson, M. D., Xu, H., Ramsay, R. G., Odom, D. T., and Flicek,P., Cohesin regulates tissue-specific expression by stabilizing highly occupiedcis-regulatory modules. Genome Res, 2012. 22(11): p. 2163-75. 

6. Deardorff, M. A., Wilde, J. J.,Albrecht, M., Dickinson, E., Tennstedt, S., Braunholz, D., Monnich, M., Yan,Y., Xu, W., Gil-Rodriguez, M. C., Clark, D., Hakonarson, H., Halbach, S.,Michelis, L. D., Rampuria, A., Rossier, E., Spranger, S., Van Maldergem, L.,Lynch, S. A., Gillessen-Kaesbach, G., Ludecke, H. J., Ramsay, R. G., McKay, M.J., Krantz, I. D., Xu, H., Horsfield, J. A., Kaiser, F. J. RAD21 mutationscause a human cohesinopathy. Am J Hum Genet, 2012. 90(6): p. 1014-27. 

7. Xu, H.*, Yan, M.*, Patra, J., Natrajan,R., Yan, Y., Swagemakers, S., Tomaszewski, J. M., Verschoor, S., Millar, E. K.,van der Spek, P. Reis-Filho, J. S., Ramsay, R. G., O'Toole, S. A., McNeil, C.M., Sutherland, R. L., McKay, M. J., Fox, S. B. Enhanced RAD21 cohesinexpression confers poor prognosis and resistance to chemotherapy in high gradeluminal, basal and HER2 breast cancers. Breast Cancer Res, 2011. 13(1): p.R9. 

8. Xu, H., J.M. Tomaszewski, and M.J.McKay, Can corruption of chromosome cohesion create a conduit to cancer? NatRev Cancer, 011. 11(3): p. 199-210.封面特写 

9. Xu, H., Balakrishnan, K., Malaterre, J.,Beasley, M., Yan, Y., Essers, J., Appeldoorn, E., Tomaszewski, J. M., Vazquez,M., Verschoor, S. Lavin, M. F., Bertoncello, I., Ramsay, R. G., McKay, M. J.Rad21-cohesin haploinsufficiency impedes DNA repair and enhancesgastrointestinal radiosensitivity in mice. PLoS One, 2010. 5(8): p. e12112 

10. Wojtasz, L., Daniel, K., Roig, I.,Bolcun-Filas, E., Xu, H., Boonsanay, V., Eckmann, C. R., Cooke, H. J., Jasin,M., Keeney, S., McKay, M. J., Toth, A. Mouse HORMAD1 and HORMAD2, twoconserved meiotic chromosomal proteins, are depleted from synapsed chromosomeaxes with the help of TRIP13 AAA-ATPase. PLoS Genet, 2009. 5(10): p. e1000702. 

11. Kudo NR, Wassmann K, Anger M, Schuh M,Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, Boer P andNasmyth K. (2006) Resolution of Chiasmata in oocytes requires separase-mediatedprotolysis. Cell, 126, 135-146. This article was selected for the frontcover of Cell 封面特写 

12. Xu, H., Beasley, M., Warren, WD., vander Horst, GTJ., and McKay, M. (2005) Absence of mouse REC8 cohesin promotessynapsis of sister chromatids in mouse. Developmental Cell, 8, 949-961. 

13. Xu, H., Beasley, M., Verschoor, S.,Inslman, A., Handel, MA and McKay, M. (2004) A new role for the mitoticRAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse.EMBO Reports, 5, 378-384. 

14. Beasley, M., Xu, H., Warren, W. andMcKay, M. (2002) Conserved disruptions in predicted coiled-coil domains ofeukaryotic SMC complexes: implications for structure and function. Genome Res,12, 1201-1209. 

15. Chen, F., Kamradt, M., Mulcahy, M.,Byun, Y., Xu, H., McKay, M.J. and Cryns, V.L. (2002) Caspase proteolysis of thecohesin component RAD21 promotes apoptosis. J Biol Chem, 277, 16775-16781. 

16. Xu, H., Swoboda, I., Bhalla, P.L. andSingh, M.B. (1999) Male gametic cell-specific gene expression in floweringplants. Proceedings of National Academy of Sciences, USA, 96, 2554-2558. 

17. Xu, H., Swoboda, I., Bhalla, P.L. andSingh, M.B. (1999) Male gametic cell-specific expression of H2A and H3 histonegenes. Plant Mol Biol, 39, 607-614. 

18. Xu, H., Swoboda, I., Bhalla, P.L.,Sijbers, A.M., Zhao, C., Ong, E.K., Hoeijmakers, J.H. and Singh, M.B. (1998)Plant homologue of human excision repair gene ERCC1 points to conservation ofDNA repair mechanisms. Plant J, 13, 823-829. 

19. Xu, H; Knox, R B; Taylor, P E andSingh, M B (1995) Bcp1, a gene required for male fertility in Arabidopsis.Proceedings of National Academy of Sciences, USA 92: 2106-2110 

20. Theerakulpisut, P; Xu, H; Singh, M B;Pettitt, J and Knox, R B (1991) Isolation and developmental expression of Bcp1,an anther-specific cDNA clone in Brassica campestris. Plant Cell3:1027-1038. 

著作:

Xu, H; Singh, M B and Knox, R B (1995)Anther-specific gene expression in Brassica and Arabidopsis In: Pollen Biotechnology:Allergens, Genes and Development. Mohapatra and Knox (eds), pp 38-52, Chapmanand Hall, London. 

国际专利:

1. Knox RB, Singh MB, and Xu H. (2001)Developmental regulation of genes in anther tissues of plants. US Patent美国专利 No. 09/036574. 

2. Knox RB, Singh MB, and Xu H. (2001)Developmental regulation of genes in anther tissues of plants. Australia Patent澳大利亚专利 No.724493. 

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